Plant Transcription Factor Database
Previous version: v3.0
Petunia axillaris
HD-ZIP Family
Species TF ID Description
Peaxi162Scf00449g00610.1HD-ZIP family protein
Peaxi162Scf00129g01043.1HD-ZIP family protein
Peaxi162Scf00503g00427.1HD-ZIP family protein
Peaxi162Scf00129g00319.1HD-ZIP family protein
Peaxi162Scf00009g00422.1HD-ZIP family protein
Peaxi162Scf00102g00931.1HD-ZIP family protein
Peaxi162Scf00346g00073.1HD-ZIP family protein
Peaxi162Scf00574g00056.1HD-ZIP family protein
Peaxi162Scf00059g00716.1HD-ZIP family protein
Peaxi162Scf00480g00058.1HD-ZIP family protein
Peaxi162Scf00878g00026.1HD-ZIP family protein
Peaxi162Scf00026g00296.1HD-ZIP family protein
Peaxi162Scf00030g00519.1HD-ZIP family protein
Peaxi162Scf00044g01613.1HD-ZIP family protein
Peaxi162Scf00190g01523.1HD-ZIP family protein
Peaxi162Scf00209g00515.1HD-ZIP family protein
Peaxi162Scf00096g01614.1HD-ZIP family protein
Peaxi162Scf00767g00212.1HD-ZIP family protein
Peaxi162Scf00030g02412.1HD-ZIP family protein
Peaxi162Scf00618g00123.1HD-ZIP family protein
Peaxi162Scf00427g00048.1HD-ZIP family protein
Peaxi162Scf00008g00428.1HD-ZIP family protein
Peaxi162Scf02095g00009.1HD-ZIP family protein
Peaxi162Scf00628g00028.1HD-ZIP family protein
Peaxi162Scf00087g00149.1HD-ZIP family protein
Peaxi162Scf00751g00058.1HD-ZIP family protein
Peaxi162Scf00099g00081.1HD-ZIP family protein
Peaxi162Scf00740g00548.1HD-ZIP family protein
Peaxi162Scf00237g01510.1HD-ZIP family protein
Peaxi162Scf00074g00025.1HD-ZIP family protein
Peaxi162Scf00069g01818.1HD-ZIP family protein
Peaxi162Scf00079g00092.1HD-ZIP family protein
Peaxi162Scf00021g00922.1HD-ZIP family protein
Peaxi162Scf00007g01020.1HD-ZIP family protein
Peaxi162Scf00171g00618.1HD-ZIP family protein
Peaxi162Scf00643g00645.1HD-ZIP family protein
Peaxi162Scf00654g00024.1HD-ZIP family protein
Peaxi162Scf00038g00093.1HD-ZIP family protein
Peaxi162Scf00040g00326.1HD-ZIP family protein
Peaxi162Scf00015g00043.1HD-ZIP family protein
Peaxi162Scf00950g00058.1HD-ZIP family protein
Peaxi162Scf00932g00044.1HD-ZIP family protein
Peaxi162Scf00233g00069.1HD-ZIP family protein
Peaxi162Scf00213g00121.1HD-ZIP family protein
Peaxi162Scf00915g00122.1HD-ZIP family protein
Peaxi162Scf00456g00213.1HD-ZIP family protein
Peaxi162Scf00040g00320.1HD-ZIP family protein
Peaxi162Scf00267g00059.1HD-ZIP family protein
Peaxi162Scf00270g00419.1HD-ZIP family protein
Peaxi162Scf00262g00121.1HD-ZIP family protein
Peaxi162Scf00063g02324.1HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401